Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (46): 7528-7532.doi: 10.3969/j.issn.2095-4344.2014.46.029

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Effect of sodium hyaluronate on malondialdehyde and superoxide dismutase levels in the synovial fluid of patients with knee osteoarthritis

Yu Qing-bo, Deng Jian-feng, Gao Da-xin, Song Hong, Yan Jia-liang, Qi Xi-ming, Wang Dong-xing   

  1. Department of Orthopedics, the First Municipal Hospital of Qinhuangdao, Qinhuangdao 066000, Shandong Province, China
  • Revised:2014-10-27 Online:2014-11-12 Published:2014-11-12
  • About author:Yu Qing-bo, Master, Physician, Department of Orthopedics, the First Municipal Hospital of Qinhuangdao, Qinhuangdao 066000, Shandong Province, China
  • Supported by:

     the Science and Technology Research and Development Plan of Hebei Province, No. 132777102D

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Abstract:

BACKGROUND: Intra-articular injection of sodium hyaluronate is an effective method for the treatment of knee osteoarthritis, with significant effect and less adverse reactions, but the mechanism is unclear.

OBJECTIVE: Through testing the malondialdehyde and superoxide dismutase levels in the synovial fluid of knee osteoarthritis before and after injection of sodium hyaluronate, to evaluate the clinical efficacy of sodium hyaluronate in the treatment of knee osteoarthritis.
METHODS: Thirty-seven patients with knee osteoarthritis (40 knees) were enrolled and divided into mild (n=10, 10 knees), moderate (n=17, 18 knees), and severe (n=10, 12 knees) groups according to the Japan's knee osteoarthritis indications. Patients were subjected to intra-articular injection of 25 mg sodium hyaluronate, once a week for 5 weeks. The levels of malondialdehyde and superoxide dismutase in the synovial fluid before and 4 weeks after treatment were detected, and then clinical effects were evaluated based on the clinical scores according to the Japan’s knee osteoarthritis indications.
RESULTS AND CONCLUSION: The indication rating results of the mild and moderate groups were decreased significantly 4 weeks after injection (P < 0.05), but there were no significant difference in the severe group before and after treatment. The malondialdehyde level in the synovial fluid was decreased obviously in the three groups at 4 weeks after injection (P < 0.05), while the level of superoxide dismutase was increased remarkably (P < 0.05). These findings indicate that sodium hyaluronate can treat knee osteoarthritis by reducing the malondialdehyde level and increasing superoxide dismutase level in the synovial fluid, but this method is more suitable for treatment of mild to moderate knee osteoarthritis.


中国组织工程研究杂志出版内容重点：组织构建；骨细胞；软骨细胞；细胞培养；成纤维细胞；血管内皮细胞；骨质疏松；组织工程


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Key words: malondialdehyde, superoxide dismutase, osteoarthritis, knee, synovial fluid

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